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Skin Conditions
Aesthetic Dermatology
Body Treatments
Injectable Treatments
Autologous Mesotherapy (PRP)
Autologous mesotherapy – or PRP (Platelet-Rich Plasma) – is a mesotherapy technique in which autologous (i.e., derived from the patient’s own blood) platelet-rich plasma is used. The patient’s platelets have the ability to gradually release growth factors at the targeted sites.
Through PRP therapy, growth factors are concentrated and activated, stimulating a greater number of stem cells. These growth factors are responsible for the effective and rapid regeneration of facial epidermal tissues.
What is the objective of autologous mesotherapy?
The objective is not the immediate filling of wrinkles, but rather the stimulation of fibroblasts. Fibroblasts subsequently produce new collagen and hyaluronic acid, as well as all the essential components of the extracellular matrix (such as elastin and glycoproteins), which are responsible for skin regeneration and hydration.
In which cases is autologous mesotherapy used on the face?
- For the correction of fine and deep wrinkles, as well as expression lines, on the face, neck, décolleté, and hands.
- For skin hydration.
- For the treatment of acne scars.
- For prevention and anti-aging purposes.
- For the treatment of hair thinning and alopecia of the scalp.
What is the procedure of autologous mesotherapy?
The procedure is simple and minimally painful. Initially, a small amount of blood is drawn from the patient and subsequently centrifuged. This process isolates the plasma rich in platelets and growth factors. The platelet-rich plasma (PRP) is then activated by the addition of a nucleotide solution and calcium ions.
Subsequently, the plasma is injected into the face, neck, or décolleté, either through targeted intradermal injections into deep wrinkles or via classical mesotherapy techniques using a needle or a dermapen device.Skin recovery is rapid, while elasticity, tone, and firmness are improved. Collagen fibers are remodeled and strengthened.
Mesotherapy with Dermapen 4
Treatment with Dermapen 4 is an advanced microneedling technique that utilizes a pen-like device equipped with multiple micro-needles to create controlled micro-injuries in the skin. This process stimulates the natural production of collagen and elastin, revitalizes the epidermis, and addresses wrinkles, fine lines, acne scars, dyschromia, and skin laxity of the face, neck, décolleté, and body.
It is a minimally invasive, regenerative treatment that improves skin texture and firmness, with customizable needle penetration depth (starting from 0.2 mm), ensuring safety even in sensitive areas.
Mechanism of Action
- Micro-punctures: The device creates thousands of microscopic channels in the skin, operating up to 104% faster than previous-generation devices.
- Regenerative Activation: These controlled micro-injuries trigger the body’s natural wound-healing mechanisms.
- Collagen Production: Fibroblasts and growth factors are activated to stimulate the synthesis of new collagen, elastin, and hyaluronic acid.
- Serum Penetration: Specially formulated serums (e.g., hyaluronic acid, vitamins) are simultaneously delivered into the deeper layers of the epidermis.
Indications
- Fine lines and wrinkles
- Acne scars and other scars (atrophic, surgical)
- Dyschromia, melasma, hyperpigmentation, and photoaging
- Skin laxity and reduced firmness
- Enlarged pores
- Striae (stretch marks)
- Rosacea
Benefits & Features
- Personalized treatment: Adjustable needle depth (0.2 mm – 3.0 mm) depending on the area and condition treated.
- Safe: Suitable for sensitive areas (neck, décolleté, hands).
- Effective: Visible improvement from the first session, with progressive enhancement over several months.
- Minimally painful: Discomfort depends on treatment depth.
Important Notes
The treatment is preferably performed during the winter months to minimize sun exposure, although it can be carried out year-round with strict photoprotection afterward.
Typically, 3–6 sessions are required at intervals of 4–8 weeks, depending on individual skin needs.
Anti-Aging Treatment with Botulinum Toxin
Mechanism of Action
The active substance inhibits the release of acetylcholine, thereby blocking neuromuscular transmission and inducing temporary muscle relaxation with reduced contractility. As muscular hyperactivity decreases, dynamic wrinkle formation is prevented.
In cases where static wrinkles are already present, treatment leads to their gradual smoothing and reduction in depth.
Treatment Areas
Botulinum toxin is commonly administered to the forehead, the glabellar region (frown lines). the lateral canthal area (“crow’s feet”), the neck, along the mandibular line.
Types of Wrinkles
- Dynamic wrinkles: Caused by repetitive muscle contractions during facial expressions. These are the primary indication for botulinum toxin treatment.
- Static wrinkles: Result from intrinsic aging processes, including decreased production of collagen, elastin, and hyaluronic acid, leading to tissue laxity. Botulinum toxin is not primarily indicated for static wrinkles; however, it may contribute to gradual improvement.
Procedure
The procedure is straightforward and takes only a few minutes. It involves the injection of small amounts of botulinum toxin into specific anatomical points, tailored to muscle activity and patient expectations.
A personalized treatment protocol is established to achieve natural, harmonious results. The full therapeutic effect stabilizes within approximately 15 days, at which point a follow-up evaluation is recommended for refinement if necessary.
Hyaluronic Acid Treatments
Wrinkle Correction
Hyaluronic acid wrinkle correction is a popular injectable treatment designed to fill facial lines and folds (such as nasolabial folds and marionette lines), restore volume to the cheeks and lips, and enhance facial contours. Results are immediate, natural-looking, and typically last 6–18 months.
The procedure involves injection of dermal filler using a fine needle or cannula following local anesthesia. It is brief, and patients may immediately resume daily activities.
Mechanism of Action
- Volumization: Hyaluronic acid fills the dermal depression, reducing wrinkle depth.
- Hydration: It attracts and binds water molecules, improving skin hydration and texture over time.
Common Treatment Areas
- Perioral area (nasolabial folds, smoker’s lines)
- Periorbital region (crow’s feet, tear trough deformity)
- Forehead and glabella
Procedure & Results
- Injection: With a fine needle or cannula.
- Session duration: 15 minutes to 1 hour.
- Immediate results: Visible immediately after application.
- Duration of action: 6 to 18 months, depending on the type of material.
Advantages
- Quick and minimally invasive
- Biocompatible synthetic material with low allergenic potential
- Natural aesthetic outcome
- Immediate return to normal activities
Facial Contouring
Facial contouring with hyaluronic acid is a non-surgical procedure designed to enhance facial angles—such as the jawline and cheekbones—creating a firmer and more harmonious profile.
Procedure
Injection of hyaluronic acid into targeted facial regions.
The session lasts approximately 20–30 minutes and is generally well tolerated.
Results
Immediate and natural-looking, with minimal to no downtime. The product is gradually resorbed, and results typically last 9–12 months.
Indications
Jawline definition, chin augmentation, cheek enhancement, and restoration of age-related volume loss.
Lip Augmentation
Hyaluronic acid is injected in controlled aliquots using a fine needle or microcannula. Under medical guidance, the patient determines the desired volume and aesthetic outcome, ensuring symmetry and natural appearance.
Post-Treatment Appearance
Mild edema is common in the first hours following treatment and usually subsides quickly. In rare cases, swelling may persist for 1–2 days and can be camouflaged with makeup.
Results are immediately visible and harmoniously integrated with the overall facial features. Patients can return to daily activities immediately.
Duration of Results
Results typically last 9–12 months. The filler is gradually biodegraded and absorbed by the body. Even after complete resorption, lip quality often remains improved due to the hydrating and regenerative properties of hyaluronic acid.
Gradual volumization through periodic touch-up sessions every 3–4 months is often preferred to maintain subtle, natural enhancement.
Facial Lipolysis Serums (PBSerum)
Pbserum products represent an innovative approach in aesthetic dermatology, enabling localized enzymatic lipolysis in a physiological manner. The treatment utilizes recombinant enzymes capable of reducing localized adipose deposits, with visible improvement often observed from the first session. Administration is performed via mesotherapy injections in a clinical setting.
Mechanism of Action
The recombinant enzymes share structural similarity with endogenous human enzymes, ensuring high biocompatibility and safety.
Lipases catalyze lipid metabolism within adipocytes, promoting reduction of localized fat deposits without damaging surrounding tissues.
The lyase enzyme provides a draining effect, eliminating molecules responsible for fluid and toxin retention, thereby improving skin appearance.
Benefits
Selective reduction of localized adiposity, reduction in circumference in over 71% of cases after two weeks, suitable for double chin and localized nasolabial fat deposits. Can be combined with mesotherapy protocols.
Procedure
The treatment is generally painless. Rarely, mild bruising or ecchymosis may occur. Immediate return to daily activities is possible. Strict photoprotection is recommended. Typically, 2–3 sessions are required, spaced 15–20 days apart, depending on severity.
Skinboosters
Skin Boosters are a specialized formulation of hyaluronic acid designed not for volumization, but for intradermal bio-stimulation. They enhance collagen synthesis and provide intensive hydration and skin revitalization across the entire face.
Administration Technique
Skin Boosters are administered via multiple microinjections into the dermis. The product contains lidocaine for improved comfort and is delivered using ultra-fine needles.
The physician maps a grid pattern to ensure even distribution, adjusting injection points based on individual skin needs.
Duration of Effect
Results last approximately 9–12 months, depending on skin condition. Newly synthesized collagen fibers continue to support firmness and elasticity beyond this period. Repeated treatments may prolong and enhance results, typically requiring maintenance every 6–9 months.
Polynucleotides
Polynucleotides are natural biopolymers (DNA/RNA fragments derived primarily from salmon) used in aesthetic medicine as potent biostimulators for skin regeneration. They stimulate fibroblasts to increase production of collagen, elastin, and hyaluronic acid, enhancing hydration, firmness, elasticity, and radiance, while addressing signs of aging, dark circles, and textural irregularities.
Key Properties and Mechanism
- Biostimulation: Act as cellular signaling molecules, promoting youthful extracellular matrix production.
- Regeneration & Hydration: Enhance tissue repair and dermal remodeling.
- Antioxidant activity: Protect against oxidative stress and free radical damage.
- Improved microcirculation: Reduce edema and periorbital dark circles.
- Natural origin: Purified fish DNA processed to eliminate allergenic potential.
Clinical Application
- Administered via intradermal injections (mesotherapy technique).
- Suitable for face, neck, décolleté, hands, body, and scalp.
- Results include improved skin texture, firmness, luminosity, wrinkle reduction, and deep hydration.